News
Announcements & Conferences
2018 National Fragile X Conference, Cincinnati, Ohio
Information here https://fragilex.org/nfxf-international-conference/
Research Briefs
2018 Fragile X Registry Newsletter
Infant Brain Development in FXS
Lighting up the search for a therapy for fragile X syndrome.
Child and Genetic Variables Associated with Maternal Adaptation to Fragile X Syndrome
Psychological Well-Being and Coping in Mothers of Youths with Autism, Down Syndrome, or Fragile X Syndrome
Study on Family Adaptation to Fragile X Syndrome: Report 1
Study on Family Adaptation to Fragile X Syndrome: Report 2
Brain Changes Associated with FX Take Place Before Age Two
Social Approach and Autistic Behavior in Children with FXS
Trajectories and Predictors of the Development of Very Young Boys with FXS
Mood and Anxiety Disorders in Females with the FMR1 Premutation
FX Registry Enrollment Update
709 adults
608 families
50 states
Selected Fragile X Publications
Behavior and Early Development
McDuffie A, Abbeduto L, Lewis P, Kim JS, Kover ST, Weber A, Brown WT. A characterization of autism spectrum disorder in children and adolescents with fragile X syndrome: Within-syndrome differences and developmental changes. American Journal on Intellectual and Developmental Disabilities. Forthcoming 2010.
Hatton DD, Wheeler A, Sideris J, Sullivan K, Reichardt A, Roberts JE, Clark R, Bailey DB. Developmental trajectories of young girls with fragile X syndrome. American Journal of Mental Retardation. 2009; 114(3): 161-171.
Roberts JE, Bailey DB, Mankowski J, Ford AF, Weisenfeld LA, Heath M, Golden RN. Mood and anxiety disorders in females with the FMR1 premutation. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2009 Jan; 150B (1):130-9.
Roberts JE, Mankowski J, Hatton DD, Baranek GT, Mirrett PL, Reznick JS, Long AC, Bailey DB. Trajectories and predictors of the development of very young boys with fragile X syndrome.Journal of Pediatric Psychology. 2009; 4: 827-36.
Abbeduto L, Murphy MM, Kover ST, Giles ND, Karadottir S, Amman A, Nollin KA. Signaling noncomprehension of language: A comparison of fragile X syndrome and Down syndrome . American Journal on Mental Retardation. 2008; 113(3): 214-230.
Baranek GT, Roberts JE, David FJ, Sideris J, Mirrett PL, Hatton DD, Bailey DB. Developmental trajectories and correlates of sensory processing functions in young children with fragile X syndrome. Physical and Occupational Therapy in Pediatrics. 2008; 28(1): 79-98.
Shanahan M, Roberts JE, Hatton DD, Reznick JS, Goldsmith H. Early temperament and negative reactivity in boys with fragile X syndrome. Journal of Intellectual Disability Research. 2008; 52: 842-854.
Murphy M, Abbeduto L, Schroeder S, Serlin R. Contribution of social and information-processing factors to eye-gaze avoidance in fragile X syndrome. American Journal on Mental Retardation . 2007; 112(5): 349-360.
Roberts JE, Weisenfeld LA, Hatton DD, Heath M, Kaufmann WE. Social approach and autistic behavior in children with fragile X syndrome. Journal of Autism and Developmental Disorder. 2007; 37(9): 1748-1760.
Cellular/Molecular Neuroscience
Malter JS, Ray BC, Westmark PR, Westmark CJ. Fragile X syndrome and Alzheimer's disease: Another story about APP and beta-amyloid. Current Alzheimer Research. Forthcoming 2010.
Westmark CJ, Westmark PR, Malter JS. Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures. Journal of Alzheimer's Disease. Forthcoming 2010.
Westmark CJ, Westmark PR, Malter JS. MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Ab. International Journal of Clinical and Experimental Pathology. 2009; 3: 56-68.
Westmark CJ, Malter JS. Translating memories: The role of protein biosynthesis in synaptic plasticity. In: Esterhouse TE, Petrinos LB, editors. Protein Biosynthesis. Hauppauge (NY): Nova; 2009. p. 195-223.
Kelley DJ, Bhattacharyya A, Lahvis G, Yin JCP, Malter JS, Davidson RJ. The cyclic AMP phenotype of fragile X and autism. Neuroscience & Biobehavioral Reviews. 2008; 32(8): 1533-43.
Kelley DJ, Davidson RJ, Elliot J, Lahvis G, Yin JCP, Bhattacharyya A. The cyclic AMP cascade is altered in the fragile X nervous system. PLoS One. 2007; 2(9): e931.
Family
Bailey DB, Sideris J, Roberts JE, Hatton DD. Child and genetic variables associated with maternal adaptation to fragile X syndrome: A multidimensional analysis. American Journal of Medical Genetics, Part A. 2008; 146(6): 720-729.
Bailey DB, Golden RN, Roberts JE, Ford AF. Maternal depression and developmental disability: Research critique. Mental Retardation Developmental Disabilities Research Review. 2007; 13(4): 321-329.
Esbensen AJ, Seltzer MM, Abbeduto L. Family well-being in Down syndrome and fragile X syndrome. In: Roberts JE, Chapman R, Warren S, editors. Speech and language development and intervention in Down syndrome and fragile X syndrome. Baltimore (MD): Brookes; 2007. p. 275-295.
Head L, Abbeduto L. Recognizing the role of parents in developmental outcomes: A systems approach to evaluating the child with developmental disabilities . Mental Retardation and Developmental Disabilities Research Reviews. 2007; 13(4): 293-301.
Lewis P, Abbeduto L, Murphy MM, Richmond EK, Giles N, Bruno L, Schroeder S, Anderson JA, Orsmond G. Psychological well-being and stress in mothers of youth with fragile X syndrome: Syndrome specificity and within-syndrome variability. Journal of Intellectual Disability Research. 2006; 50: 894-904.
Abbeduto L, Seltzer MM, Shattuck P, Krauss MW, Orsmond G, Murphy MM. Psychological well-being and coping in mothers of youths with autism, Down syndrome, or fragile X syndrome. American Journal of Mental Retardation. 2004; 109: 237-254.
Language Development
Abbeduto L, Brady N, Kover ST. Language development and fragile X syndrome: Profiles, syndrome-specificity, and within-syndrome differences. Mental Retardation and Developmental Disabilities Research Reviews. 2007; 3: 36-46.
Abbeduto L, McDuffie A. Language learning and use as embedded social activities: Evidence from autism and fragile X syndrome. In: Paul R, editor. Language disorders from a developmental perspective: Essays in honor of Robin S. Chapman. Mahwah (NJ): Lawrence Erlbaum Associates Publishers; 2007. p 195-214.
Murphy M, Abbeduto L. Gender differences in repetitive language in fragile X syndrome. Journal of Intellectual Disability Research. 2007; 51 (5): 387-400.
Robert J, Martin G, Moskowitz L, Harris A, Foreman J, Nelson L. Discourse skills of boys with fragile X syndrome in comparison to boys with Down syndrome. Journal of Speech, Language & Hearing Research. 2007; 50(2): 475-492.
Barnes E, Roberts J, Mirrett P, Sideris J, Misenheimer J. A comparison of oral structure and oral-motor function in young males with fragile X syndrome and Down syndrome. Journal of Speech, Language & Hearing Research. 2006; 49(4): 903-917.
Neurobiology
Hoeft F, Carter JC, Lightbody AA, Cody Hazlett H, Piven J, Reiss AL. Region-specific alterations in
brain development in one- to three- year old boys with fragile X syndrome. Proceedings of the National Academy of Sciences. 2010; 107(20): 9335-9339.